I. Core Product Advantages

• Targeted Anti-Inflammation with Mild Irritation: As an NSAID, carprofen can selectively inhibit the activity of cyclooxygenase-2 (COX-2), accurately block the synthesis of prostaglandins (inflammatory mediators), and control inflammatory responses at the source, while exerting minimal irritation to the gastrointestinal tract and kidneys of cattle. Clinical studies have confirmed that it can effectively inhibit acute and chronic inflammation, and moderately regulate the humoral and cellular immune functions of cattle, adapting to the tolerance characteristics of cattle at different physiological stages.
• Excellent Pharmacokinetics with Long-Lasting Efficacy: After a single subcutaneous injection in cattle, it is rapidly and completely absorbed, with a peak time of about 8 hours, stable peak plasma concentration, an average elimination half-life of up to 55.69 hours, and a bioavailability of as high as 104.96%. A single dose can achieve long-lasting anti-inflammatory and analgesic effects without frequent re-injections, which not only reduces the stress response of cattle caused by frequent catching and administration but also saves breeding labor costs.
• Convenient Administration and Wide Application Scenarios: It supports two administration routes: subcutaneous injection and intravenous injection, among which subcutaneous injection is more suitable for mass operation in large-scale breeding. The dosage is easy to calculate and control—only 1ml per 35kg body weight (1.4mg/kg based on carprofen). It is available in two package specifications: 50ml and 100ml. The multi-dose vial design can meet the needs of different breeding scales, and the efficacy remains stable within 28 days after opening.
• Safe, Compliant and Beneficial to Breeding Benefits: Produced in strict accordance with veterinary drug production standards, all excipients meet pharmacopoeia standards. The finished product has been verified by stability tests, with a shelf life of up to 24 months when stored in a sealed container protected from light below 30℃. The withdrawal period is only 21 days, and the milk discard period is 0 hours—dairy cows do not need to stop milk production during treatment for diseases, minimizing breeding losses. Only transient local reactions at the injection site may occur after administration, with no serious adverse reactions.

II. Main Indications for Treatment

• Acute Infectious Respiratory Diseases: Targeting symptoms such as fever (body temperature above 39.5℃), cough, wheezing, shortness of breath, listlessness, and anorexia caused by bacterial and viral respiratory infections in cattle. It is especially suitable for acute respiratory inflammation in calves, fattening cattle, and adult dairy cows, which can quickly relieve congestion and edema of lung and respiratory tract mucosa, and effectively reduce discomfort in sick cattle.
• Acute Mastitis: Targeting local symptoms such as breast swelling and increased skin temperature caused by acute mastitis in dairy cows, as well as accompanying systemic symptoms including fever, depression, sudden decrease in milk production, and abnormal milk quality (turbidity, flocculent substances). It can effectively inhibit the inflammatory response of mammary tissue, relieve pain, and help sick cattle quickly recover their feeding and milk production functions.

III. Clinical Therapeutic Effects

• Rapid and Significant Symptom Relief: When used in combination with antibacterial drugs, it can effectively reduce the fever of sick cattle within 24-48 hours, relieve respiratory symptoms such as cough and wheezing, or mastitis symptoms such as breast swelling and pain. Clinical data show that the decrease rate of serum inflammatory factors (such as PCT) in the combined use group is significantly faster than that in the group using only antibacterial drugs, and the average clinical symptom score decreases by more than 60% within 3 days.
• Thorough Inflammation Control and Low Recurrence Rate: By inhibiting the production of prostaglandins E1, E2, and osteoclast-activating factors, it comprehensively blocks the inflammatory cascade reaction, which not only relieves superficial symptoms but also eliminates deep tissue inflammation. The recommended dosage of 1.4mg/kg achieves the best curative effect, which is equivalent to that of similar products. There is no significant difference in efficacy between medium and high dosages, effectively avoiding the risks associated with excessive medication.
• Improved Overall Treatment Success Rate: When antibacterial drugs are used alone, some sick cattle suffer from insufficient feeding and decreased physical fitness due to severe inflammation and unbearable pain, which further affects the treatment effect. After combined use with this product, the comfort of sick cattle is significantly improved, appetite is quickly restored, and body resistance is enhanced. The clinical treatment success rate is increased by 15%-20% compared with single antibacterial treatment, and the adjuvant therapeutic effect is more prominent in severe cases.

IV. Usage Notes