Albendazole is a synthetic anthelmintic which belongs to the group of benzimidazole-derivatives with activity against a broad range of worms and at a higher dosage level also against adult stages of liver fluke.
Albendazole combined with eelworm's microtubule protein and play a role. After albenzene combined with β- tubulin, it can prevent dimerization between albenzene and α tubulin assembling into microtubules. Microtubules are the basic structure of the many cell units. Albendazole's affinity to nematodes tubulin is significantly higher than the affinity of mammalian tubulin, so toxicity to mammalian is small.
Prophylaxis and treatment of worminfections in calves and cattle like:
Gastrointestinal worms: Bunostomum, Cooperia, Chabertia, Haemonchus, Nematodirus,Oesophagostomum, Ostertagia, Strongyloides and Trichostrongylus spp.
Lung worms: Dictyocaulus viviparus and D. filaria.
Tapeworms: Monieza spp.
Liver-fluke: adult Fasciola hepatica.
Albendazole has also an ovicidal effect.
Administration in the first 45 days of gestation.
For oral administration.
For roundworms ,tapeworms:
Cattle / buffalo / horse / sheep / goat: 5mg/kg bodyweight
Dog / cat: 10 to 25mg/kg bodyweight
Cattle/buffalo: 10mg/kg bodyweight
Sheep/goat: 7.5mg/kg bodyweight
Calves and cattle: 1 bolus per 300 kg. body weight.
1 bolus per 250 kg. body weight.
Keep out of reach of children.
- For meat : 12 days.
- For milk : 4 days.
Store in tightly cool, dry place protected from light.